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The severity is dose-dependent

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These changes often include: More visible cellulite Looser or deflated appearance of the thighs Reduced volume in the legs Skin that appears uneven or creased Areas where fat loss unmasks existing skin quality issues These changes are common and rooted in predictable physiology, not a sign of something wrong. Understanding why they happen can help you make informed, empowered decisions about your body and your options

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J Neurol Sci 139:2733 Levine JB, Kong J, Nadler M, Xu Z (1999) Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors