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Semaglutide in Singapore: Uses, Benefits, and Side Effects Jul 28, 2025 (Last updated: Feb 20, 2026 ) 7 Minutes Read Medically Reviewed By: Dr Leonard Leng MBBS, MMed (FM), GDOM, DWD Weight Loss Medication, Semaglutide vs Other GLP-1 Agonists, Side Effects & Safety Precautions GLP-1 agonist medications may be considered for adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related condition , such as high blood pressure, type 2 diabetes, or sleep apnea

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GLP-1 stands for glucagon-like peptide-1, which is a hormone naturally produced in your gut

While exenatide provides clinically meaningful glycemic control, its impact on weight loss is relatively modest compared to more recent GLP-1R agents, resulting in less than 3 kg of weight reduction over a 30-week period (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

Clin Chim Acta 1982;122:369-75

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