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The effects of the treatment last days or weeks after the procedure

As cited above, a key manifestation of oxidative damage to oocytes in endometriosis is comprised by aberrations in the organization of oocyte meiotic spindles and chromosomes, a key morphologic marker for ROS damage and a widely regarded harbinger of impending oocyte and fetal aneuploidy (62, 84, 85)

In fact, pharmacological NPC1 inhibition applying the amphipathic steroid U18666A in SH-SY5Y cells previously served as a model for NPC disease [57, 58]

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