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USA , 116 , 9433-9442, doi: Zhang, J., Pavlova, N

Blood sugar fluctuations, insulin resistance, and mitochondrial strain increase: Oxidative stress Pro-inflammatory cytokine signaling Nervous system reactivity Impaired cellular recovery Even subtle metabolic instability can make pain more persistent and resistant to conventional treatment

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Glucocorticoids inhibit neutrophil apoptosis and demargination