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Impaired transport of leptin across the bloodbrain barrier in obesity

Rather than engaging a single high-affinity receptor, the pentadecapeptide modulates multiple intersecting cellular pathways including nitric oxide system signalling, growth-factor receptor expression (notably VEGF receptor 2 and growth-hormone receptor), dopamine and serotonin pathway markers, and angiogenic factor regulation

However, the high cost of these drugsOzempic, for example, costs approximately $969 per month has led to challenges in patient access and insurance reimbursement

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10.1038/s41401-021-00768-4 37 DorseyE

For those living with endometriosis this is an exciting development