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In the LOOK AHEAD trial (N=5,145), intensive lifestyle intervention producing 8.6% weight loss at year 1 was associated with significantly less kidney function decline over 4 years compared to usual care (JASN 2014, Gregg et al.)

Pediatric Children should receive lower doses according to their age, body weight, and physical condition

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For those three regimens, proportions of women who gained more than 10% in weight were 51%, 32%, and 23%, and proportions of men 42%, 27%, and 18%