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Genetic Factors Alteration of the Transsulfuration Pathway One of the classic alterations of the homocysteine metabolism is represented by the homozygous deficiency of CBS (Mudd et al, 1995)

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These suggested that the increased expression of nuclear p53 and progerin in intrahepatic cells could be strongly linked to cell premature senescence in human liver fibrosis

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Ergothioneine Oxidation in the protection against High-Glucose Induced Endothelial Senescence: Involvement of SIRT1 and SIRT6