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Prunes or prune juice, which contain both fiber and sorbitol (a natural laxative), may be particularly effective

But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

Research-grade products sold online are unregulated, untested for human use, and carry real risks ranging from contamination to inaccurate dosing

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