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Abdominal Pain and Cramping : While abdominal pain is a common side effect of semaglutide for all users, it may be more intense for those without a gallbladder
Presented for research literature review only Luo X et al
Tirzepatide causes some side effects during the first few weeks and the dose escalation period, such as nausea, vomiting, diarrhea and constipation
For instance, in the pivotal SURPASS-2 trial, patients receiving the highest tirzepatide dose (15 mg) achieved a mean body weight reduction of 11.2 kg, nearly twice that observed with semaglutide 1 mg (5.7 kg) (19)
According to Joesph, this underlines the fact that aggressive weight loss interventions to try and achieve remission need to happen early in the diabetes journey. This study suggests that a combination of following a very low-calorie diet and semaglutide might be an effective way to help manage type 2 diabetes
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