No significant associations between SNPs and CGMS data, insulin dose, C-peptide max , AUC C-peptide30 , AUC C-peptide180 , CP 120 , CP 180 response of 24 weeks treatment were observed in SAXA group
In Taiwans National Health Insurance program, the cost of a GLP-1RA (e.g., liraglutide) can be up to 7 times that of insulin (e.g., insulin glargine) per treatment cycle (e.g., US$108.6 versus US$15.4 per month) [6]
In STEP TEENS, suicidal ideation was reported in 4 participants on semaglutide (3.9%) versus 0 on placebo [2]
Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint
Kwok et al
There are a few key players in the world of medications for type 2 diabetes, and these (generally speaking!) are those key players