Glutathione in IV has proven more effective than oral administration since it bypasses the digestive system, thus omitting the chances of bloating and abdominal cramps frequent with oral supplements
Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine
Bassino, E., Gasparri, F
This upregulation exhausts intracellular GSH, leading to ROS buildup and oxidative DNA damage that can ultimately generate TP53 mutations, a process that is halted when CHAC1 is knocked down (Wada et al., 2018)
Hi Jennifer, Its hard to tell without testing my motto is test dont guess but many herbs work for both bacterial and fungal overgrowth
Second, and more importantly, the dose-response was biphasic