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Ranieri, R
Citation: Wharton, S., Batterham, R
however, as yet, no inhibitor with pharmacological potential has been identified
In the Discussion we consider whether the oxidation of cysteine residues might still be obscured by other routes of countervailing sulfenate/disulfide reduction
Onset, IV: 2-3 mins
Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies
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