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W., Levine, J., Gershon, S., Stanley, J
To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor
All measurements were normalized by the total protein levels and the results reported in moles of GSH per gram of protein
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The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins
Glutathione is a highly reactive antioxidant known to react with oxygen in the air
