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For patients in whom GLP-1 receptor agonists are not suitable, NICE NG28 recommends several alternative classes of glucose-lowering therapy

Your weight plateau may be a clue to uncovering potential medical issues, such as: Thyroid disorders : Hypothyroidism may slow your metabolism to a crawl, making it hard to continue losing weight, even on Ozempic Hormonal imbalances : Conditions like PCOS, prediabetes, type 2 diabetes, and other conditions related to insulin resistance can impact how your body processes food and stores fat Chronic stress : Elevated cortisol (the stress hormone) over time tells your body to hold onto fat, especially around your middle, as a survival mechanism Sleep apnea or poor sleep quality : Sleep issues may disrupt your hunger hormones, making you feel hungrier and crave ultraprocessed or non-nutritious foods Additionally, some medications might be quietly working against your weight loss efforts

Current patterns with existing GLP-1 medications suggest variable coverage across provinces, often with prior authorization requirements and restrictions to patients with specific BMI thresholds or comorbidities

Wegovy and contraception When taking Wegovy, you must use contraception to avoid getting pregnant, as it is not known if the medication can affect your unborn baby