(2021) reported lower Clostridium group IV in PD as well as no strongly associated taxa with levodopa (L-DOPA) use, although preliminary data suggest Clostridium cluster IV may be linked to short-term motor-symptom response to L-DOPA, which deserves a thorough controlled validation
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[11] In one crossover study, patients with bipolar disorder on lithium were given either 15 mg or 300 mg of MB daily, and those on the higher dose experienced significantly less depression, suggesting efficacy at that dose, though side effects and long-term safety at such high doses remain concerns
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