We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs
He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, et al
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Examination of the expression patterns for selected early SA-induced genes indicated that their activation by SA required the TGA2/5/6 subclass of transcription factors