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Currently, there are few ongoing clinical trials with peptide polyagonists in NASH, including tirzepatide (SYNERGY-NASH
However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists
Nonetheless, ePA ensures that, when coverage is allowed, a patients initiation onto therapy is not prevented by paperwork, potentially capturing the drugs value
Absalon Gutierrez, associate professor and endocrinologist at the University of Texas Health Houston, says constipation is the most common change in bowel habits he sees
& Jawade, S
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