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As the degradation of CRBN neosubstrates can be a major concern in the development of CRBN-based degraders 16,107,108,109 , a lack of independent CRBN affinity is likely a benefit that minimizes the chance of eliciting off-target neosubstrate degradation, as we see for dHTC1

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Determination of some kinetic and characteristic properties of glutathione [PMID: 18221006] Laboratory literature summary: Determination of some kinetic and characteristic properties of glutathione S-transferase from bovine erythrocytes

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