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Balance the potential benefits against the practical reality of managing multiple sources of gastrointestinal disturbance
10.1038/s41591-018-0128-1 121 RodriguezJ.PierreN.NaslainD.BontempsF.FerreiraD.PriemF.et al (2017)
In addition, although the widely used version of the ANT requires adjustment for age and educational attainment, a study from Japan has reported that such adjustments did not substantially change the diagnostic accuracy [109]
Furthermore, it was demonstrated that GLP-1 receptor plays a regulatory role in the hippocampal function and GLP-1 receptor agonists enhanced GABAA signaling through pre-and postsynaptic mechanisms in rats [57], while exendin-4 therapy normalized cognitive dysfunction and improved impaired hippocampal synaptic plasticity in a mice model of diet-induced obesity [58]
The Look AHEAD: Action for Health in Diabetes (Look AHEAD) trial on the longer-term effects of an intensive lifestyle intervention in adults who were overweight/obese with type 2 diabetes showed improvements in diabetes control and complications, depression, physical function and health-related quality of life, sleep apnoea, incontinence, brain structure and healthcare use and costs, with positive impacts on composite indices of multimorbidity, geriatric syndromes and disability-free life-years
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