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Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support

for example, the site of conjugation of the linker can affect the PK of the ADCs through effects on stability while the ADC is within circulation or after internalization and more unstable linkers may lead to a faster decline in antibody concentrations [20]

Standard Weekly Dose Escalation Protocol Dose Escalation Criteria Advance to the next dose level after 4 weeks if: Tolerated current dose with minimal side effects Adequate clinical response observed Patient adherence maintained No contraindications developed Dose Adjustment for Side Effects If significant gastrointestinal side effects occur: Maintain current dose for an additional 24 weeks Consider temporary dose reduction Provide symptomatic management Re-escalate when tolerated Individualization Tailor titration based on: Patient tolerance and side effects Therapeutic response Clinical goals Comorbid conditions Clinical Pearls: Gradual titration significantly reduces the incidence and severity of gastrointestinal side effects (nausea, vomiting, diarrhea) that are common during initiation of GLP-1 receptor agonist therapy

A plateau doesnt necessarily mean tirzepatide has stopped working

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