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Specifically, Frias et al

Importantly, while GLP-1 inhibits glucagon release to reduce hepatic glucose output, GIP can stimulate glucagon secretion under certain conditions, such as low glucose states, which may represent an adaptive mechanism to maintain glucose supply during fasting or stress 3

Anything outside that range means discard

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A compounded version relies on shorter-term stability data specific to that particular formulation and compounding process

Bifidobacterium lactis has the strongest evidence for improving constipation