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Women who have never given birth to an infant (nulliparity) or are at a very late stage are at higher risk compared to women who have given birth to multiple infants (multiparity) ( Hormones further play a pivotal role in the molecular classification of breast cancer in different subtypes and the response to treatment based on their presence or absence ( ESR1 , are associated with acquired resistance (intrinsic or extrinsic) to endocrine therapies ( 2.2 Genetic predisposition as risk factors In the past 1015 years, the genetic landscape of breast cancer has undergone substantial evolution, which highlights the properties of several genes that can drive hereditary susceptibility with moderate or high penetrance

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Annals of Pharmacotherapy 1995