Johnstone AM, Murison SD, Duncan JS, Rance KA, Speakman JR: Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine
Progress in brain research
Researchers have found that differences in the GLP1RA gene , which encodes the GLP-1 receptor, influence how much weight someone is likely to lose on these medications
You've got enough that the signal gets saturated
it addresses the full spectrum of metabolic dysfunction, from blood sugar imbalance to fatty liver disease and systemic inflammation
There are also parts in Africa and the Middle east with high obesity numbers, but they do not get the same attention, yet