A trial with Mediterranean mussels showed that high Cu2+ concentrations led to valve closure and a decreased heart rate in mussels (55)
In vitro studies on human keratinocytes show a reduction in inflammatory cytokine production of over 50%
However, patients requiring high-dose B12 (e.g., for pernicious anemia) may need separate injections
Developing and testing a new drug is expensive, and companies count on recouping their costs by having, in effect, a monopoly on the market for a new drug
In more rare yet severe cases, you may experience: Itching or a feeling of swelling all over the body Muscle cramps and weakness Upset stomach and urinary problems Swelling in the ankles or feet Unusual tiredness Irregular heartbeat or trouble breathing If these side effects occur, consult your healthcare provider before continuing B12/MIC
So the skin rationale is the best-supported of any goal here, while still involving a significant leap from topical data to injected blends