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Ice-cold MeOH (600 L), CHCl 3 (200 L), and H 2 O (500 L) samples were vortexed and then centrifuged (10,000 g , 10 min, 4 C) to precipitate proteins

It plays roles as an antioxidant and an anti-toxin, effectively providing a major defense system against illness and aging

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Notably, CD8 T cells within the TME exhibit increased susceptibility to ferroptosis because of lipid peroxidation and the downregulation of the activity of antioxidants such as glutathione peroxidase 4 [308]

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