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As DiMarchi points out, 'What you're trying to do is take two individual keys and make a master key that is every bit as effective as the two individual parts.' To their surprise they noticed that mice lost more weight when injected with a balanced dual agonist than when given one more centred on GLP-1
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As indications have expanded from diabetes to obesity, GLP-1RAs have increasingly entered routine care for women of reproductive age, including those with PCOS, in whom obesity and insulin resistance are highly prevalent (36, 38, 43)
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