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Bansal N, Hudda M, Payne RA, Smith DJ, Kessler D, Wiles N
Acarbose Based on 13 publication(s) in Google Scholar Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor ( IC 50 =11 nM)
GLP-1RAs excel at inducing short-term weight loss by imposing a powerful external satiety signal, whereas postbiotics may contribute to stabilizing the endogenous signaling environment that governs appetite regulation and metabolic adaptation ( Adipose tissue plasticity and thermogenic capacity: BAT, browning, and the physiological ceiling in humans The discovery of metabolically active BAT in adult humans raised expectations that obesity therapies might meaningfully increase energy expenditure through thermogenesis ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure ( Importantly, the physiological ceiling on BAT-mediated thermogenesis implies that increasing energy expenditure is unlikely to offset the metabolic adaptation associated with rapid weight loss
Top-line results of the Phase 2 trial demonstrated metopimazine led to a 40% reduction in the incidence of nausea and a 56% reduction in frequency of vomiting
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