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In PD, pairing novel markers, such as seed amplification assays and extracellular vesicle cargo profiling, with specialized imaging modalities (e.g., neuromelanin-sensitive MRI, susceptibility-weighted imaging for iron deposition) has yielded superior diagnostic accuracy and staging resolution [603, 604]

Energy metabolites including ATP, ADP, and creatine phosphate reflect the follicular energetic status and correlate with oocyte developmental competence [229, 230]

The acyl group on CoA can now be transferred to carnitine and the resulting acyl-carnitine transported into the mitochondrial matrix