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It works upstream in the hormone cascade, offering a physiologic and highly controlled way to enhance hormone levels
Its active form, 1,25(OH)2D, regulates mucosal immunity, host defense, and inflammation by binding to the vitamin D receptor (VDR) in macrophages [73, 74], triggering the expression of the antimicrobial peptide cathelicidin (CAMP) (LL-37) and promoting autophagosomelysosome fusion and maturation [16, 75]
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Arnon, T
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