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GHK-Cu was placed in Category 2 in 2023 alongside several other peptides including BPC-157, TB-500, and MOTS-c

Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: February 28, 2026 GHK-Cu is a copper peptide complex (glycyl-histidyl-lysine combined with copper) that naturally occurs in human saliva, plasma, and urine

End-stage renal disease or severe hepatic impairment requires caution

La toxicidad cutnea es menor que con otros frmacos similares, y se ha descrito algn caso aislado de erupcin cutnea inespecfica y dermatitis exfoliativa120, y tambin eritrodisestesia palmoplantar, xerosis y decoloracin de la piel121

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