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Ussher JR, Baggio LL, Campbell JE, et al
GLP-1 is the now-famous weight loss hormone that drugs like Ozempic and Wegovy mimic, and amyloid is a hallmark of Alzheimers disease
While GLP-1s can be powerful tools for weight loss and metabolic health, they dont permanently change the biology that made weight management challenging in the first place
Patient preference, taken seriously but not in isolation
Ozempic, Wegovy, and Mounjaro for Weight Loss Compounded semaglutide is an unregulated version of the medication, often lacking consistency and safety compared to Ozempic, Wegovy, and Mounjaro, which are FDA-approved for weight loss
The underlying mechanisms for these beneficial effects appears to be the convergence of complementary signaling pathways and physiological effects (e.g., reduced glucotoxicity, weight loss and BP reduction for SGLT2 inhibitor and reduced glucose-dependent glucagon secretion and anti-inflammatory effects for DPP-4 inhibitor) for beneficial effects on CV health or suppression of microvascular complications [220, 223]
