how long does it take for semaglutide to lose weight The Pros and Cons of Loss How Effective Is Semaglutide for

Compared to sitagliptin, GLP-1 analogues are more effective in reducing HbA1C (weight mean difference 0.41%, 95% CI 0.51 to 0.31) and body weight (weight mean difference 1.55 kg, 95% CI 1.98 to 1.12)

Long-term side risks could consist of the body generating antibodies against the drug, which could reduce its efficacy or cause new side effects

Accessed 23 June 2025

Reduced NGF signaling may weaken cavernous nerve repair capacity and increase vulnerability to inflammatory injury (84)

GLP-1 also affects food intake, body weight, and has direct effects on the heart (52, 103)

Liraglutide is also prescribed under the brand name Victoza