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Step 5: Your First Injection If you meet safety criteria, you may receive your first GLP-1 injection during your appointment

Develop multispecific constructs (e.g., IL-13R2/EGFRvIIICD3 trispecifics) to address heterogeneity, and consider integrating immune agonists (IL-15 superagonists) or TGF- traps to potentiate effector function

Discontinuation and weight regain: plan long term Weight maintenance after stopping therapy is a known concern

Data are plotted as means SD (n = 3 biologically independent samples)

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