In UK clinical settings, the recognised standard diluent for injectable medicines is Water for Injections BP (single-use, preservative-free), and the choice of diluent must always follow the licensed product's Summary of Product Characteristics (SmPC)
This yielded an initial set of 1259 motifs, which were then filtered to exclude repetitive motifs or any motifs fewer than four base pairs in length, yielding the final set of 1209 motifs (Swindell et al., 2013)
Avoid repeated freezethaw cycles
Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation
Krivic, A., Majerovic, M., Jelic, I
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