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The SURPASS-4 clinical trial was a non-inferiority study comparing tirzepatide to insulin glargine where tirzepartide showed superior A1c and body weight reductions from baseline in adults with T2DM at increased CVD risk.[20] Also, tirzepatide reported a higher occurrence of individuals achieving an A1c below 7% compared to insulin glargine

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What the STEP clinical trials actually show Numbers matter

Practices should request prior authorization for high-cost drugs billed under J3490 whenever payer policy requires it, and obtain written documentation of the authorization before administering the drug

Jackson-Jones, L

Low protein intake, limited cysteine or glycine, selenium deficiency, mitochondrial dysfunction and poor glutathione recycling may further reduce antioxidant reserve