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The main limitation is that it uses population-average half-life values without adjustment for individual factors like body weight, kidney function, or age

72,73,74 Additionally, ASOs regulate transcription via steric hindrance, influencing specific splicing of pre-mRNA and selectively altering the expression of specific proteins

doi: 10.1002/mnfr.201500031 11

Appreciating the triple agonist action helps explain why retatrutide might succeed in people that have done poorly on other therapies

Colmers et al., 2012