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This is the most current guidance based on available safety data
Similarly, the appetite-suppressing effects of liraglutide have been traced to its action within the arcuate nucleus (ARC) of the hypothalamus, a region also characterized by a relatively permeable BBB (Secher et al., 2014)
3,4 This enzymatic cleavage not only inactivates GLP-1 but also generates metabolites that may act as antagonists at the GLP-1 receptor
Otberg N, Richter H, Schaefer H, Blume-Peytavi U, Sterry W, Lademann J
"PTEN identified as important risk factor of chronic obstructive pulmonary disease"