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The FDA is also taking steps to combat misleading direct-to-consumer advertising and marketing following warning letters that were sent in the fall of 2025

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After starting semaglutide, you may notice you feel more exhausted than usual, leading you to ask, Why am I so tired on semaglutide? Semaglutide fatigue is usually temporary

Do not change the dose, dosing frequency, or treatment duration without talking to your health care professional