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Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence

and from the German Research Council Priority Programme, SPP 1468 - Immunobone (CRC1181) and the German Federal Ministry of Education and Research (BMBF) project METARTHROS (to G.S.)

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doi:10.1016/S0021-9258(18)46868-8

The liquid blend of these nutrients is absorbed quickly and more efficiently compared to food supplements