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Beyond simple additive effects, well-designed combination platforms can achieve true pharmacological synergy wherein the combined effect exceeds the sum of individual agent activities through mechanisms including chemo-sensitization, efflux pump inhibition, autophagy modulation, or simultaneous targeting of proliferation and survival pathways
Nat Rev Mol Cell Biol (2021) 22(2):7595
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Oral glutathione evidence is more recent but increasingly robust, particularly for longer durations (3-6 months) and liposomal formulations
The conversation shifts from 'What unknown thing is causing this problem?' to 'How do we manage the known physiological responses to GH elevation?' That is a world of difference
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