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SBP reduction was mostly mediated by weight loss (7794%) in SURPASS-1, -2 and -3, while mechanisms independent from weight loss accounted for most of the tirzepatide benefit on SBP in SURPASS-4 and -5 (57 and 73%, respectively) [77]
All four products contain the same drug semaglutide but differ in route of administration, dose range, and licensed indication
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Experts also worry it leaves people vulnerable to developing an unhealthy relationship with food and their bodies
The 2 mg injectable dose is orders of magnitude lower than oral therapeutic doses, though subcutaneous bioavailability is higher than oral bioavailability
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