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Therefore, lets think about an elephants butt instead

Without it, the structure of the drug might be just wrong enough to cause problems

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Zhang S, Rocourt C, Cheng W-H

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples

The depalmitoylation inhibitor ML348 was able to ameliorate synaptic dysfunction and cognitive-motor deficits in S transgenic mice by inhibiting the palmitoylation of estrogen receptor (ER)