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Tirzepatide (Mounjaro, Zepbound) is technically a dual GIP/GLP-1 receptor agonist, hitting two incretin receptors instead of one, which explains its superior weight loss outcomes in clinical trials
The landmark COMBINE study (Anton et al., 2006) found that both naltrexone and structured behavioral support improved drinking outcomes, supporting a combined approach that addresses both the biological and behavioral sides of alcohol use
Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(-/-) Knockout Mouse
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