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Significant reductions in waist circumference, blood pressure, triglycerides, and fasting glucose were observed
Weight loss often becomes apparent in weeks one to four due to reduced snacking and liquid calories, then slows after week 12 as intake and metabolism adapt
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A greater proportion of semaglutide-treated participants improved their BMI category from baseline to week 68 compared with placebo (see Figure full abstract)
Poulsen, Daniela Giustarini, Ranieri Rossi, Flemming Dela, Jrn W
Clinical trials do not separate these psychological responses from pharmacological mood changes
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