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Some users report joint discomfort during significant weight loss phases, likely related to the mechanical and structural adaptations required as load-bearing changes

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Both are contraindicated in pregnancy for the same clinical reasonslack of human safety data and preclinical fetal effects

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It is the first in a new class of drugs that inhibit the proteolytic activity of dipeptidyl peptidase-4, thereby potentiating the action of endogenous glucoregulatory peptides, known as incretins