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Highest efficacy is typically experienced at the higher doses
Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
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Because of this effect, and the fact that perihelion occurs just after the December solstice (with aphelion happening shortly after the June solstice), the "December solstice" side of the analemma is much larger, with bigger time differences, while the "June solstice" side is much narrower, with smaller departures from the mean time
Journal of Ethnopharmacology , 136(3), 378384
JMIR Infodemiology (2025)
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