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Key Findings - Design: Prospective, single-arm, open-label study - Participants: 16 adults with obesity and type 2 diabetes - Intervention: Tirzepatide 2.5 mg (4 weeks) 5 mg (8 weeks) Metabolic Improvements - Glucose infusion rate (GIR) from 3.21 to 5.16 mg/min/kg - HbA1c from 7.95% to 6.14% - Body weight by 4.9 kg (5%) - Fat mass by 9.1%, muscle mass by 1.8% - Glucagon from 28.8 to 20.8 pg/ml No Correlation Found - GIR changes werent significantly linked to other clinical variables Your Voice Matters: As GLP-1/GIP therapies evolve, should early improvements in insulin sensitivity influence how we define treatment success beyond weight loss and HbA1c

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