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This approach exists for a specific reason: starting at a higher dose produces stronger side effects, particularly nausea and digestive discomfort, that make treatment difficult to tolerate and sustain

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While the main findings indicate that semaglutide reduced total SAEs by 8% and atrial fibrillation by 31%, it also may increase a persons risk of deep vein thrombosis (DVT) by 266% (RR 3.66, 95% CI 1.0912.25

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That is why controlled trials exist: to separate the product's pharmacological action from everything else

doi: 10.1080/10937400903442514 14 BastosE