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Moreover, while oral drugs need to be stable enough to survive the enzymatic degradation in the stomach and liver, IN-delivered drugs face fewer challenges due to the relatively lower expression of enzymes in the nasal mucosa
[19] [20] Patients with anxiety disorders may be particularly sensitive to perceived heart rate changes and benefit from education about expected physiologic effects versus symptoms requiring medical attention
2025, pp
In a study targeting suicide attempts as the endpoint, a control group with a higher prevalence of depression and suicidal ideation might lead to outcome bias, as evidenced by the increased incidence of suicidal ideation within the control group
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