Oral tirzepatide is a pill form of the breakthrough weight loss medication that acts on two key gut hormones, GIP and GLP-1
Ohio State Health & Discovery
GLP-1 medications more commonly known by their brand names Ozempic, Mounjaro, and Wegovy are being used by diabetic patients as well as weight loss patients to help reduce feelings of hunger
Monitoring for Dysesthesia in Clinical Practice Baseline Assessment (Before Starting Retatrutide) Neurological Screening: Check for pre-existing neuropathy (diabetes, B12 deficiency) Document baseline sensation in hands/feet Review medications that affect nerves Assess risk factors (alcohol use, vitamin deficiencies) Patient Education: About 1 in 5 to 1 in 8 patients on the highest dose develop abnormal sensations like tingling or numbness (20.9% in TRIUMPH-4, 12.5% in TRIUMPH-1)
While it is unclear how widespread the practice is, internet forums including Reddit have numerous examples of people reporting that they have been injecting themselves with such DIY preparations
Inflammation 42 (5), 15851594